Search results for "model [interaction]"

Progeria: Model Organisms

2019

The use of whole-mountin situhybridization to illustrate gene expression regulation

2014

In situ hybridization is a widely used technique for studying gene expression. Here, we describe two experiments addressed to postgraduate genetics students in which the effect of transcription factors on gene expression is analyzed in Drosophila embryos of different genotypes by whole-mount in situ hybridization. In one of the experiments, students analyzed the repressive effect of Snail over rhomboid expression using reporter lines containing different constructs of the rhomboid neuroectodermal enhancer fused to the lacZ gene. In the second experiment, the epistatic relationship between the cabut and decapentaplegic genes was analyzed. These simple experiments allowed students to (1) unde…

Calculation and inversion of two-dimensional gravity in the vicinity of Lake Tuz, Turkey

2000

Abstract An example of gravity inversion and interpretation is presented which demonstrates how a priori information can be used to derive reliable, though complex models. In this case, the geometry of the studied model profile has been constructed on the basis of seismic and geological data. The densities used in the forward calculations were obtained from laboratory measurements of drill cores, from density-velocity relationships, and from Nettleton’s method of fitting gravity and topography. In the seismic section 21 ‘formations’ are distinguished leading to a very complex gravity model. What is called ‘formations’ here, are two-dimensional bodies which are distinguished from each other …

German bank lending to industrial and non-industrial countries: driven by fundamentals or different treatment?

2005

This paper shows that the substantial disparity in German bank lending towards industrial (IC) and non-industrial (Non-IC) countries is largely explained by differences in countries' endowments and only to a minor extent by German banks' different treatment of these country groups. This is demonstrated by applying a decomposition technique to an augmented gravity model that is estimated for German foreign lending using a new micro panel data-set on individual claims from the Deutsche Bundesbank covering the period from 1996 to 2002.

Application of the International classification of functioning, disability and health in Taiwan : victory of the medical model

2017

AbstractSince July 2012, eligibility for disability benefits and services in Taiwan has been assessed based on the International Classification of Functioning, Disability and Health. This study examines disabled people’s experiences of this new assessment system: does it incorporate the social model or a multidimensional understanding of disability and assess the needs of disabled people adequately? In-depth interviews were employed with 24 disabled persons to answer these questions from the perspective of disabled people. The findings show that the new assessment model is still medicalised: social roles and social participation are not considered, the assessment process is dominated by pro…

Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.

2011

BackgroundPrevious studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in the environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed that postnatal ENU treatment induced lasting deficits in proliferation of neural progenitors in the subventricular zone (SVZ), the main neurogenic region in the adult mouse brain. The present study is aimed to examine, in mice exposed to ENU, both the structural features of adult neurogenic sites, incorporating the dentate gyrus (DG), and the behavioral performance in tasks sensitive to manipulations of adult neurogenesis.Methodology/principal findin…

Phage-driven loss of virulence in a fish pathogenic bacterium

2012

Parasites provide a selective pressure during the evolution of their hosts, and mediate a range of effects on ecological communities. Due to their short generation time, host-parasite interactions may also drive the virulence of opportunistic bacteria. This is especially relevant in systems where high densities of hosts and parasites on different trophic levels (e.g. vertebrate hosts, their bacterial pathogens, and virus parasitizing bacteria) co-exist. In farmed salmonid fingerlings, Flavobacterium columnare is an emerging pathogen, and phage that infect F. columnare have been isolated. However, the impact of these phage on their host bacterium is not well understood. To study this, four s…

Introducing the Time Series Change Visualization and Interpretation (TSCVI) method for the interpretation of global NDVI changes

2021

Abstract This paper presents a novel method for the visualization of changes in vegetation related variables. This method, termed Time Series Change Visualization and Interpretation (TSCVI), allows to summarize changes associated to both vegetation productivity and phenology in a single map. To that end, three metrics are retrieved on an annual basis from plotting NDVI (Normalized Difference Vegetation Index) values on a polar plot. Changes in these metrics are then analyzed and mapped in an IHS (Intensity Hue Saturation) image, where colors indicate changes regarding the growing-season (earlier or later occurrence, stronger or weaker seasonality), while changes associated to productivity a…

Global aerosol modeling with MADE3 (v3.0) in EMAC (based on v2.53): model description and evaluation

2019

Recently, the aerosol microphysics submodel MADE3 (Modal Aerosol Dynamics model for Europe, adapted for global applications, third generation) was introduced as a successor to MADE and MADE-in. It includes nine aerosol species and nine lognormal modes to represent aerosol particles of three different mixing states throughout the aerosol size spectrum. Here, we describe the implementation of the most recent version of MADE3 into the ECHAM/MESSy Atmospheric Chemistry (EMAC) general circulation model, including a detailed evaluation of a 10-year aerosol simulation with MADE3 as part of EMAC. We compare simulation output to station network measurements of near-surface aerosol component mass con…

Model Doświadczania Globalizacji (MDG) i wstępna wersja Skali Doświadczania Globalizacji (SDG)

2018

The aim of article is attempt to answer for the question: what effects does globalization have on the individual self-realization and psychological development? In this paper globalization is understood among others as the process of universalizing economic and social rules. Individual effects of this process are varied. Relationship between globalization and psychological condition of man is theoretically describe by the Model of Experience of Globalization (MDG). Based on the original model was constructed Globalization Experience Scale (SDG). This scale can measure the cognitive and affective reaction to globalization. Globalization Experience Scale (SDG) have a 14 statements which measu…